5 Essential Elements For cees dekker
5 Essential Elements For cees dekker
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‘Of course, that is about appropriate. I search for a Bodily idea of biological techniques inside of a bottom-up way. I believe you could potentially distinguish three traces of exploration in my group at this time. The very first worries chromosome composition: how do you get yourself a metre-very long DNA polymer folded and organised in such a microscopic cell? We've got designed visualisation procedures that permit us to review how, one example is, SMC proteins loop DNA (online video on Youtube) in order to Construct up chromosomes.
Our team scientific tests bacterial cell division which is aiming to constitute a ‘bottom up biology’ in artificial cells that will autonomously divide. Our principal interest lies in mobile division, chromatin construction, and spatial Manage.
‘It absolutely was basically a make a difference of picking up a reserve on mobile biology and starting to read. I'd come from a globe of extremely-significant vacuums, cryostats and quantum phenomena, and now I used to be working at home temperature with molecular biology kits.
Sculpting nano-electrodes by using a transmission electron beam for electrical and geometrical characterization of nanoparticles.
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Our research ranges in the biophysics of DNA to synthetic cells and beyond. Please take a look down below for the spectrum of our present-day jobs.
All parameters ended up a similar for each panel Within this video clip, apart from the Preliminary placement on the 6hb rod (demonstrated in blue) over the nanopore. Simulations that terminated early due to translocation from the rod throughout the pore are marked by a grey track record.
Instance (one) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in grey, the rim with the pore is highlighted in crimson, in addition to a 3D ceesdekker rendering in the movement from the DNA rod is exhibited.
‘Sure, I have an understanding of folks ended up shocked at enough time. At the conclusion of the nineties, when I was in my forties, I used to be Professor of Molecular Electronics and I've to admit that it had turn into a little bit bored, I didn’t find out A great deal any more. The field went extra into the application aspect, how you could potentially integrate nanotubes into electronic circuits.
Resolving the phase measurement in condensin-driven DNA loop extrusion identifies ATP binding because the stage-generating procedure
An integrated microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
1999, first measurement with the wavefunction of single molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for just a new Luttinger description of interacting electrons in nanotubes
2005, discovery on the system of DNA uncoiling by topoisomerase enzymes; discovery of extended-vary conformational alterations in Mre11/DNA maintenance complexes; and initially force measurements on the DNA molecule inside of a nanopore
‘I'm pushed by marvel and questions. On a material degree I uncover solutions in physics, but I working experience my deepest happiness with God. That faith also drives my science and how I handle men and women.